Spike Protein & Cell Aging (2023)

2023

This 2023 study finds that the SARS-CoV-2 spike protein can induce retinal pigment epithelial (RPE) cell senescence (aging) by activating the ROS/P53/P21 pathway. This pathway contributes to cellular aging in RPE cells and suggests a way through which the virus may affect the health and function of the retina. To mitigate the effects of reactive oxygen species (ROS) and possibly interfere with the pathway leading to cell senescence, NAC (N-acetylcysteine) is recommended. NAC is known for its antioxidant properties and ability to replenish glutathione levels.

Zhang Y, Peng X, Xue M. et al. (2023). SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway. Biogerontology 24, 813-827.